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CELL DISSECTION
Nano-blade Array for Spatial Dissection of Single Cells and Tissues |
 Kyohei Terao, Faculty of Engeneering, Kagawa University
go to Terao Lab. HOMEPAGE
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Nano-blade Array for Spatial Dissection of Single Cells and Tissues
We study spatial distribution of biomolecules in a tissue and a cell to understand biological processes such as organ development and formation of cell polarity. Si nano-blade array MEMS device can sample single cells and intracellular biomolecules with keeping spatial information in tissues or in single cells. Using the device, we demonstrated successful dissection of single cells into subcellular fractions.
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Fig. (left) SEM images of the device
Fig. (right) Fluorescence images after cell dissection. Upper right numbers
show the size of the blade gap
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