Microfluidic MEMS for Delivering Chemicals to Single Cells
We study MEMS application to
biotechnology. A novel microfluidic
MEMS can deliver
chemicals to single cells and observe their intracellular responses. For
developing understanding of the mechanism that a β-cell secretes insulin in
response to the rise of glucose concentration in the blood, the microfluidic MEMS
allows us to deliver glucose to a limited area of a single β-cell, and to
observe its insulin granules.
Fig.(upper) Microfluidic MEMS device
Fig.(below) Experimental reslts on cell culture in Microfluidic MEMS device
K. Terao, A. Okonogi, A. Fuke, T. Okitsu, T. Suzuki, M. Washizu, H. Kotera:
“Localized substance delivery to single cell and 4D imaging of its uptake using a flow channel with a lateral aperture”
Microfluidics and Nanofluidics, 12, 423-429 (2012).